Related Experiment Video
Updated: Jul 12, 2026

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
[Immunisation schedule of the Spanish Association of Paediatrics: 2020 recommendations]
Francisco José Álvarez García1, María José Cilleruelo Ortega2, Javier Álvarez Aldeán3
1Centro de Salud de Llanera, Severies, Asturias, España; Departamento de Medicina, Universidad de Oviedo, Oviedo, España.
Insights
The updated Spanish childhood immunization schedule recommends a 2+1 vaccine regimen for infants and boosters for older children. Key updates include routine rotavirus, meningococcal B, and HPV vaccines for all children, enhancing protection against serious diseases.
Area of Science:
- Pediatrics
- Immunology
- Public Health
Background:
- The Spanish Association for the Prevention of Accidents (CAV-AEP) annually reviews and updates the optimal childhood immunization schedule based on scientific evidence.
- Current vaccination practices aim to provide comprehensive protection against vaccine-preventable diseases in children residing in Spain.
Purpose of the Study:
- To present the latest recommended childhood immunization schedule for Spain for the upcoming year.
- To incorporate new evidence and recommendations for vaccines against diseases like rotavirus, meningococcal B, and HPV.
Main Methods:
- The CAV-AEP's annual publication synthesizes available scientific evidence and expert consensus.
- Recommendations are based on efficacy, safety, and public health impact assessments.
Main Results:
- A 2+1 schedule (2, 4, 11 months) using hexavalent vaccines (DTPa-VPI-Hib-HB) and 13-valent pneumococcal conjugate vaccine is recommended.
- Routine vaccination for rotavirus, meningococcal B (2+1 schedule), and HPV (for both genders at 12 years) is advised. Tdap boosters are recommended for adolescents and during pregnancy.
- MMR and varicella vaccines are recommended with two doses, and MenACWY vaccine is recommended at 12 months (replacing MenC) and 12 years.
Conclusions:
- The updated schedule aims to maximize protection against a wider range of infectious diseases in children and adolescents.
- Emphasis is placed on universal vaccination, including HPV for both genders, and catch-up vaccination strategies.
- The schedule integrates new vaccines and optimizes existing ones for improved public health outcomes in Spain.
Abstract:
The CAV-AEP annually publishes the immunisation schedule considered optimal for all children resident in Spain, taking into account the available evidence. The 2+1 schedule is recommended (2, 4, and 11 months) with hexavalent vaccines (DTPa-VPI-Hib-HB) and with 13-valent pneumococcal conjugate. A 6-year booster is recommended, preferably with DTPa (if available), with a dose of polio for those who received 2+1 schemes, as well as vaccination with Tdpa in adolescents and in each pregnancy, preferably between 27 and 32 weeks. Rotavirus vaccine should be systematic for all infants. Meningococcal B vaccine, with a 2+1 schedule, should be included in routine calendar. In addition to the inclusion of the conjugated tetravalent meningococcal vaccine (MenACWY) at 12 years of age with catch up to 18 years, inclusive, the CAV recommends this vaccine to be also included at 12 months of age, replacing MenC. Likewise, it is recommended in those over 6 weeks of age with risk factors or who travel to countries with a high incidence of these serogroups. Two-dose schedules for MMR (12 months and 3-4 years) and varicella (15 months and 3-4 years) will be used. The second dose could be applied as a tetraviral vaccine. Universal systematic vaccination against HPV is recommended, both for girls and boys, preferably at 12 years, and greater effort should be made to improve coverage. The 9 genotype extends coverage for both genders.
Related Concept Videos
Vaccinations
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Immunodeficiency Diseases
There are three main causes of immunodeficiency disorders...
Drug Dosing: Infants and Children
Vaccines
Respiratory Syncytial Virus Disease

