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Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Diterpenoids and Flavonoids from Andrographis paniculata.

Tran Thi Hong Hanh¹, Nguyen Thi Thuy My², Pham Thi Cham¹

¹Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST).

Chemical & Pharmaceutical Bulletin

|January 7, 2020

Summary

Andrographis paniculata yielded nine compounds, including novel ones. Andropanolide showed significant anticancer activity and inhibited nitric oxide production in immune cells.

Keywords:

Acanthaceae Andrographis paniculata cytotoxicity diterpenoid flavonoid nitric oxide overproduction

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Area of Science:

Phytochemistry
Pharmacology

Background:

Andrographis paniculata is a medicinal plant with a history of traditional use.
Its chemical constituents are of interest for potential therapeutic applications.

Purpose of the Study:

To isolate and characterize compounds from the aerial parts of Andrographis paniculata.
To evaluate the cytotoxic and anti-inflammatory potential of the isolated compounds.

Main Methods:

Phytochemical investigation involving isolation and structure elucidation using NMR and MS.
In vitro assays to determine cytotoxicity against various cancer cell lines.
Assessment of nitric oxide inhibition in LPS-stimulated macrophages.

Main Results:

Nine compounds were isolated, including a new ent-labdane diterpenoid (andrographic acid methyl ester) and a new chalcone glucoside (pashanone glucoside).
Andropanolide exhibited cytotoxicity against LNCaP, HepG2, KB, MCF7, and SK-Mel2 cells (IC50: 31.8–45.9 µM).
Andropanolide significantly inhibited nitric oxide production in RAW264.7 macrophages (IC50: 13.4 µM).

Conclusions:

The study identified novel and known compounds from Andrographis paniculata.
Andropanolide demonstrates promising anticancer and anti-inflammatory properties, warranting further investigation.