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A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
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Data on producing an infusion fluid that contains nitric oxide
Yoshihiro Tange1, Shigenori Yoshitake1, Wataru Watanabe1
1Department of Medical Engineering, Kyushu University of Health and Welfare, Nobeoka City, Japan.
Data in Brief
|January 8, 2020
Summary
Researchers developed an intravenous infusion fluid containing nitric oxide (NO), offering a simpler therapeutic delivery method. This novel NO-infused fluid could be crucial for conditions with compromised NO production, like ischemia.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Pharmacology
Background:
- Nitric oxide (NO) is a vital vasodilator and platelet inhibitor.
- Current NO therapy for pulmonary hypertension involves inhalation.
- Nitrite (NO2-) is a proposed intravascular source for NO delivery.
Purpose of the Study:
- To develop an easier method for therapeutic nitric oxide (NO) delivery.
- To create an intravenous infusion fluid containing NO.
- To investigate the potential of NO-infused fluids for conditions with compromised NO production.
Main Methods:
- Production of two solutions: nitrogen gas injected (control) and NO gas injected (experimental).
- Measurement of NO concentrations using a Microplate Photometer and NO assay kit.
- Analysis of gas profiles using an i-STAT system.
- Quantification of total nitrite (NO2-) and nitrate (NO3-) to assess NO levels via the Griess method.
Main Results:
- Successful production of an infusion fluid containing NO.
- Demonstration of NO presence in the experimental solution.
- Comparison of in vitro and ex vivo gas profiles and NO concentrations between control and experimental solutions.
Conclusions:
- An intravenous infusion fluid containing nitric oxide (NO) was successfully produced.
- This novel fluid offers a potentially simpler alternative to inhaled NO therapy.
- The developed infusion fluid could be beneficial in ischemic conditions where NO production is impaired.
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