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Updated: Dec 31, 2025

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
Origin and evolution of the human immunodeficiency virus: where is it coming from, where is it going?
Martine Peeters1, Marie-Laure Chaix2
1Université de Montpellier-I, UMI233, TransVIHMI, IRD, 911, avenue Agropolis, 34394 Montpellier, France.
Abstract:
Simian immunodeficiency viruses (SIV) have been described in at least 45 non-human primate species. SIVs from chimpanzees and gorillas from West Central Africa have crossed the species barrier on at least four occasions leading to HIV-1 in humans. HIV-2 viruses result from at least eight to nine independent transmissions of SIVs infecting sooty mangabeys from West Africa. These HIV variants have different virological and epidemiological histories. Only HIV-1 group M is responsible for the global epidemic and can be subdivided into nine subtypes and a wide diversity of circulating (CRFs) and unique (URFs) recombinant forms. The highest genetic diversity of HIV-1 M is observed in the Democratic Republic of Congo and HIV-1 strains started to spread globally from this area. The heterogeneous HIV-1 M subtype/CRF distribution is the result of founder effects related to demographic factors such as travel and migration. The genetic diversity of HIV-1 continues to increase overtime due to co- or superinfections. In addition, the expanded access to antiretrovirals leads to an increasing number of drug-resistant strains, especially in resource limited countries.
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