Related Experiment Video
Updated: Dec 31, 2025
In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function
Published on: October 15, 2013
La réponse interféron de type I est-elle efficace pour contrôler l'infection par HTLV-1 ?
Raphaël Bernard-Valnet1, Kimberly Berthet1, Maxime Bisseux1
1École normale supérieure, Master Biosciences, département de biologie, 46, allée d'Italie, 69007 Lyon, France.
Abstract:
Innate immunity plays a critical role in the host response to a viral infection. In particular, type I interferons (IFN-I) are major effectors of antiviral innate immunity. Herein, interplays between HTLV-1 and the IFN-I response are reviewed. Particular emphasis is put on virus sensing by innate immunity receptors and on anti-HTLV-1 effects of IFN-I. We also discuss HTLV-1-induced alteration of IFN-I function and how IFN-I/AZT treatment of adult T-cell leukemia/lymphoma patients can lead to complete remission despite virus-induced escape mechanisms.
