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Direct Reprogramming of Mouse Fibroblasts into Melanocytes
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Remodelage cellulaire par les Phytovirus
Romain Grangeon1, Jean-François Laliberté1
1INRS-institut Armand-Frappier, 531, boulevard des Prairies, Laval, Québec, H7V 1B7, Canada.
Virologie (Montrouge, France)
|January 9, 2020
Summary
Plant viruses reprogram cells, creating specialized viral factories from host membranes for replication. This review explores viral factory formation, its metabolic impact, and role in cell-to-cell virus movement.
Area of Science:
- Plant virology
- Cell biology
- Molecular plant-microbe interactions
Background:
- Plant cells undergo significant changes upon viral infection.
- Viral replication relies on specialized structures called viral factories.
- These factories are derived from host cell membranes.
Purpose of the Study:
- To review the biogenesis of various viral replication factories.
- To discuss the impact of viral factory formation on plant cell metabolism.
- To describe the role of viral factories in virus cell-to-cell movement and plasmodesmata modification.
Main Methods:
- Literature review of plant virus-host interactions.
- Analysis of studies on viral factory formation and function.
- Synthesis of information on metabolic alterations and cell-to-cell transport.
Main Results:
- Different types of viral factories are formed during infection.
- Viral factories significantly impact host cell metabolism.
- These factories are crucial for virus movement through plasmodesmata.
Conclusions:
- Viral factories are key sites for plant virus replication and spread.
- Understanding viral factories offers insights into host-pathogen interactions.
- Targeting viral factories could be a strategy for disease control.
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