Related Experiment Video
Updated: Dec 31, 2025
05:19
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
Published on: July 7, 2023
3.1K
Device-Based Modulation of Neurocircuits as a Therapeutic for Psychiatric Disorders.
Zhi-De Deng1,2, Bruce Luber1, Nicholas L Balderston3
1Noninvasive Neuromodulation Unit, Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA;
Annual Review of Pharmacology and Toxicology
|January 10, 2020
Summary
Device-based neuromodulation is a promising psychiatric treatment. This review covers tools for identifying and modulating brain circuits, clinical evidence, and future directions in brain stimulation therapies.
Area of Science:
- Neuroscience
- Psychiatry
- Biomedical Engineering
Background:
- Device-based neuromodulation is an emerging therapeutic strategy for psychiatric disorders.
- Identifying and targeting specific neurocircuits is crucial for effective treatment.
- Existing brain stimulation techniques vary in invasiveness and efficacy.
Purpose of the Study:
- To review recent advances in tools for neurocircuit identification and modulation.
- To summarize clinical evidence for the efficacy of circuit modulation in psychiatric disorders.
- To discuss strategies for improving neuromodulation precision and explore future research directions.
Main Methods:
- Review of clinical evidence for various brain stimulation approaches (subthreshold, subconvulsive, convulsive, neurosurgical).
- Analysis of tools for identifying and modulating neurocircuits.
- Survey of cutting-edge research in novel neuromodulatory paradigms and devices.
Main Results:
- Significant progress has been made in developing tools for neurocircuit targeting.
- Clinical evidence supports the therapeutic efficacy of diverse brain stimulation techniques.
- Strategies for enhancing precision and efficacy are actively being developed.
Conclusions:
- Device-based neuromodulation offers a promising avenue for psychiatric treatment.
- Continued advancements in technology and understanding of neurocircuits will enhance therapeutic outcomes.
- Novel paradigms and next-generation devices are poised to revolutionize psychiatric care.
