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Author Spotlight: Advancing Understanding of Age-Related Lens Stiffness Changes
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Corneal biomechanics in different age groups.

Ahmed Abdel Karim El Massry1, Amr Ahmed Said1, Ihab Mohamed Osman1

  • 1Ophthalmology Department, Faculty of Medicine, Alexandria University, 311, Horeya Avenue, Sporting, 10th Floor, App 1004, Alexandria, Egypt.

International Ophthalmology
|January 10, 2020
PubMed
Summary

Corneal hysteresis (CH) and corneal resistance factor (CRF) decrease with age in normal individuals. Intraocular pressure (IOP) measurements, IOPg and IOPcc, show minimal age-related changes.

Keywords:
BiomechanicsCorneaHysteresisIOPResistance factor

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Corneal Physiology

Background:

  • Corneal biomechanical properties are crucial for ocular health and refractive surgery outcomes.
  • Understanding age-related changes in corneal biomechanics is essential for accurate intraocular pressure assessment.
  • The Ocular Response Analyzer (ORA) provides key metrics like corneal hysteresis (CH) and corneal resistance factor (CRF).

Purpose of the Study:

  • To investigate age-related variations in corneal biomechanical parameters (CH, CRF) and intraocular pressure (IOPg, IOPcc) in a normal population.
  • To stratify these parameters across different age decades using the Ocular Response Analyzer (ORA).
  • To explore correlations between ORA parameters and demographic factors like age and gender.

Main Methods:

  • A cross-sectional survey of 997 eyes from 508 normal individuals was conducted.
  • Participants were categorized into age groups by decade (10-20, 21-30, 31-40, 41-50, >50 years).
  • ORA measurements for CH, CRF, IOPg, and IOPcc were recorded and analyzed for age and gender correlations.

Main Results:

  • A statistically significant negative correlation was observed between increasing age and both CH and CRF.
  • CH and CRF values showed a decline with advancing age across the studied decades.
  • IOPcc remained relatively constant across age groups, while IOPg exhibited an initial decrease followed by a gradual increase.

Conclusions:

  • Corneal biomechanical properties, specifically CH and CRF, demonstrably decrease with age in healthy individuals.
  • Age has a minimal impact on IOPg and IOPcc, suggesting their relative stability across the lifespan.
  • These findings highlight the importance of considering age in the interpretation of corneal biomechanical and IOP measurements.