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Published on: September 11, 2017
The Role of Circular RNAs in Brain Injury
Huaxin Zhu1, Zelong Xing2, Yeyu Zhao2
1Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Nanchang 330006, Jiangxi, China; Department of Preventive Medicine, Jiujiang University, No. 57, Xunyang East Road, Yuyang District, Jiujiang 332000, Jiangxi, China.
Abstract:
Circular RNAs are an increasingly important topic in non-coding RNA biology, drawing considerable attention in recent years. Accumulating evidence suggests a critical role for circular RNAs in both early and latent stages of disease pathogenesis. Circular RNAs are abundantly expressed in brain tissue, with significant implications for neural development and disease progression. Disruption of these processes, including those seen in response to brain injury, can have serious consequences such as hemiplegia, aphasia, coma, and death. In this review, we describe the role of circular RNAs in the context of brain injury and explore the potential connection between circular RNAs, brain hypoxic ischemic injury, ischemia-reperfusion injury, and traumatic injury.
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