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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
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Bright carbon nanodots for miRNA diagnostics coupled with concatenated hybridization chain reaction
Guangxing Liu1, Hua Chai, Yuguo Tang
1Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, P. R. China.
Chemical Communications (Cambridge, England)
|January 11, 2020
Abstract:
We developed a bright carbon nanodot-based miRNA detection method with signal amplification by concatenated hybridization chain reaction (CHCR). In the presence of target miRNA, CHCR was triggered and a frond-like DNA product was formed, which recovered remarkable fluorescence. The location and level of the target miRNA were then indicated.
