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Updated: Dec 31, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Mapping migraine to a common brain network.

Matthew J Burke^1,2,3, Juho Joutsa^1,4,5, Alexander L Cohen^1,6

¹Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Brain : a Journal of Neurology

|January 11, 2020

Summary

This summary is machine-generated.

Migraine brain imaging findings consistently link to a specific network involving the visual cortex (V3/V3A), insula, and hypothalamus. This discovery offers a unified understanding and a potential target for migraine neuromodulation therapies.

Keywords:

connectivity migraine networks neuroimaging neuromodulation

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Last Updated: Dec 31, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Modeling the Functional Network for Spatial Navigation in the Human Brain

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

Area of Science:

Neuroimaging
Neuroscience
Brain Network Mapping

Background:

Migraine neuroimaging studies show inconsistent findings, hindering symptom localization and therapeutic target identification.
Novel brain network mapping techniques offer a promising approach to link imaging results to neuroanatomy and treatment targets.

Purpose of the Study:

To determine if heterogeneous neuroimaging findings in migraine patients localize to a common brain network.
To identify a common neuroanatomical substrate for migraine symptomatology using advanced network mapping.

Main Methods:

Utilized meta-analytic coordinates of decreased grey matter volume in migraineurs as seed regions.
Generated resting-state functional connectivity network maps from a normative connectome (n=1000).
Employed Bayesian spatial generalized linear mixed models and region of interest analyses for specificity evaluation against chronic pain and Alzheimer's disease control groups.

Main Results:

All migraine coordinates (100%) showed negative connectivity to left extrastriate visual cortex (V3/V3A).
Over 90% of coordinates exhibited positive connectivity with the insula and negative connectivity with the hypothalamus.
Left V3/V3A was identified as the most specific connectivity area for migraine compared to control groups.

Conclusions:

Coordinate-based network mapping reveals that grey matter loss in migraineurs localizes to a common brain network connected to visual cortex V3/V3A.
This network, implicated in cortical spreading depression, offers a unified perspective on migraine neuroimaging.
The findings propose V3/V3A as a specific, novel target for migraine neuromodulatory treatments.