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Microperimetry in Age-Related Macular Degeneration: An Evidence-Base for Pattern Deviation Probability Analysis in
Nicola K Cassels1, John M Wild1, Tom H Margrain1
1College of Biological and Life Sciences, Cardiff University, Cardiff, UK.
Translational Vision Science & Technology
|January 11, 2020
Summary
Microperimeter color coding for visual field sensitivity is unreliable for age-related macular degeneration (AMD) assessment. Standard Total and Pattern Deviation analyses should replace color designations for accurate interpretation of visual field loss.
Area of Science:
- Ophthalmology
- Visual Neuroscience
- Medical Imaging
Background:
- Microperimetry utilizes color-coded differential light sensitivity, unlike standard automated perimetry's probability analyses.
- The reliability of microperimeter color designations in representing visual field abnormalities is not well-established.
Purpose of the Study:
- To evaluate if microperimeter color designations correlate with established Pattern Deviation probability analyses.
- To determine the accuracy of color-coded sensitivity in identifying visual field defects in age-related macular degeneration (AMD).
Main Methods:
- Calculated Total and Pattern Deviation probability levels at 40 stimulus locations in healthy individuals.
- Applied these probability levels to microperimetry data from 45 AMD patients.
- Assessed the correlation between color designations and probability levels.
Main Results:
- Green color codes generally indicated normal sensitivity.
- Red/black color codes typically corresponded to significant visual field loss (P ≤ 1%).
- Orange color codes spanned all probability levels, offering no clear diagnostic information.
Conclusions:
- Green and red/black color codes offer some indication of normal and abnormal results, respectively.
- The orange color code is unreliable for interpreting visual field status in AMD.
- Total and Pattern Deviation analyses are recommended over color coding for accurate visual field assessment in AMD.
