Five primary disparate melanomas: a case report (the spectrum of melanoma)

A 75-year-old Caucasian female presented with a 20-year history of five primary disparate malignant melanomas and one small desmoplastic amelanotic satellite. In three generations, there was no family history of dysplastic nevi or malignant melanoma. Likewise, the patient had no history of dysplastic nevi or any other condition previously reported in the literature as being allied with melanoma. Dr. George Pack first reported that malignant melanoma may be multifocal. The wide spectrum of this disease and increased incidence of multiple primaries demand thorough, long term, follow-up.