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Whole-brain morphometric studies in alcohol addicts by voxel-based morphometry
Jinfeng Li1, Yonghao Wang2, Zhengyang Xu1
1Department of Radiology, The First Medical Center of PLA General Hospital, Beijing 100853, China.
Annals of Translational Medicine
|January 14, 2020
Summary
Alcohol addiction is linked to significant white matter and brain parenchyma volume reductions. Voxel-based morphometry (VBM) can detect subtle brain atrophy in alcohol addiction patients.
Area of Science:
- Neuroimaging
- Neuroscience
- Radiology
Background:
- Alcohol addiction is a chronic relapsing brain disease.
- Morphological brain changes are associated with alcohol addiction.
Purpose of the Study:
- Investigate whole-brain morphological changes in alcohol addiction patients using voxel-based morphometry (VBM).
Main Methods:
- 20 alcohol addiction patients and 20 healthy controls underwent 3.0T MRI scans.
- Voxel-based morphometry (VBM) analyzed whole-brain MRI images.
- Independent samples t-test compared brain volumes between groups.
Main Results:
- Patients with alcohol addiction showed significantly reduced gray matter volume in specific frontal and precuneate gyri.
- White matter volume (WMV) and brain parenchyma volumes (BPVs) were significantly smaller in alcohol addiction patients.
- No significant difference in overall gray matter volume (GMV) was observed.
Conclusions:
- Alcohol addiction is associated with widespread brain atrophy, particularly in white matter and brain parenchyma.
- VBM is a valuable tool for detecting subtle brain atrophy in alcohol addiction.
- VBM may aid in the diagnosis of alcohol addiction.
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