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Related Concept Videos

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Imaging-assisted anticancer nanotherapy.

Anshuman Dasgupta1, Ilaria Biancacci1, Fabian Kiessling1

  • 1Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, Aachen, Germany.

Theranostics
|January 16, 2020
PubMed
Summary
This summary is machine-generated.

Imaging advances cancer nanomedicine by improving drug delivery and efficacy. This integration aids in understanding drug distribution and personalizing cancer treatments for better patient outcomes.

Keywords:
anticancer nanotherapycancer nanomedicinesnanotheranostics

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Area of Science:

  • Oncology
  • Nanomedicine
  • Medical Imaging

Background:

  • Cancer nanomedicines improve drug delivery, reduce toxicity, and enhance efficacy, leading to approved treatments for various cancers.
  • Combining nanomedicines with imaging offers insights into tumor targeting and addresses variability in the Enhanced Permeability and Retention (EPR) effect.
  • Nanotheranostics and companion diagnostics are emerging strategies in imaging-assisted cancer nanotherapy.

Purpose of the Study:

  • To summarize recent advancements in imaging-assisted anticancer nanotherapy.
  • To discuss future strategies for enhancing cancer nanomedicine performance in patients.
  • To highlight the role of imaging in understanding and optimizing nanomedicine delivery.

Main Methods:

  • Review of preclinical and clinical studies integrating imaging with nanomedicine.
  • Exploration of strategies like traditional imaging, companion diagnostics, and nanotheranostics.
  • Non-invasive and quantitative assessment of nanocarrier biodistribution and drug release.

Main Results:

  • Imaging enables non-invasive assessment of nanocarrier biodistribution, target accumulation, and drug release.
  • Clinical imaging shows promise for patient stratification, crucial for nanomedicine translation.
  • Progress in understanding tumor-targeted drug delivery and addressing EPR heterogeneity.

Conclusions:

  • Imaging integration is vital for optimizing cancer nanomedicine delivery and efficacy.
  • Patient stratification using imaging is essential for successful clinical translation of nanomedicines.
  • Future strategies should focus on further improving imaging-assisted nanotherapy performance.