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Association between standardized vitamin 25(OH)D and dyslipidemia: a community-based study in Riyadh, Saudi Arabia
AlJohara M AlQuaiz1,2, Ambreen Kazi3,4, Randa M Youssef2
1Princess Nora Bent Abdullah Chair for Women's Health Research, King Saud University, PO, Box 231831, Riyadh, 11321, Kingdom of Saudi Arabia.
Environmental Health and Preventive Medicine
|January 17, 2020
Summary
Vitamin D deficiency is common in Saudi Arabia and linked to unhealthy cholesterol levels. Low HDL cholesterol is associated with deficiency in men, while high triglycerides are linked in women.
Area of Science:
- Endocrinology
- Cardiovascular Health
- Nutritional Science
Background:
- High prevalence of vitamin D deficiency and cardiovascular disease risk factors in Saudi Arabia.
- Dyslipidemia, including altered lipid profiles, is a significant contributor to cardiovascular diseases.
Purpose of the Study:
- To investigate the association between vitamin D deficiency and dyslipidemia in a Saudi population.
- To analyze the relationship between serum 25-hydroxyvitamin D levels and lipid parameters (total cholesterol, LDL, HDL, TG) in apparently healthy adults.
Main Methods:
- Cross-sectional study involving 1717 healthy Saudi participants aged 30-75 years.
- Data collection included interviews, anthropometric measurements, and blood sample analysis.
- Serum 25-hydroxyvitamin D (25(OH)D) measured via electrochemiluminescence; lipid panel analyzed using automated enzymatic methods.
Main Results:
- Vitamin D deficiency was associated with lower HDL cholesterol in males (ORA = 2.1) and a trend in females (ORA = 1.3).
- Vitamin D deficiency was significantly associated with higher triglycerides in females (ORA = 3.0) but not in males.
- Analysis adjusted for potential confounders using multivariable logistic regression.
Conclusions:
- Vitamin D deficiency is highly prevalent in the Saudi population.
- Specific dyslipidemia patterns, low HDL in men and high TG in women, are linked to vitamin D deficiency.
- Treatment of vitamin D deficiency is recommended for the general population to mitigate cardiovascular risks.
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