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Lung volume changes during histamine-induced bronchoconstriction in recurrently wheezy infants
D L Maxwell1, A Prendiville, A Rose
1Department of Medicine, Royal Post-graduate Medical School, Hammersmith Hospital, London, England.
Pediatric Pulmonology
|January 1, 1988
Summary
Histamine inhalation challenges in wheezy infants caused increased functional residual capacity (FRC). These changes, especially at higher doses, may lead to underestimation of airflow reduction in infant respiratory studies.
Area of Science:
- Pediatric Pulmonology
- Respiratory Physiology
Background:
- Recurrent wheezing in infants is a common respiratory issue.
- Accurate assessment of lung function is crucial for managing pediatric respiratory diseases.
Purpose of the Study:
- To investigate the impact of histamine challenge on functional residual capacity (FRC) in infants with recurrent wheezing.
- To evaluate if changes in FRC affect the measurement of airflow limitation.
Main Methods:
- Respiratory inductance plethysmography was employed to measure FRC changes.
- Infants underwent histamine challenge with increasing concentrations.
- Maximum flow at FRC (Vmax FRC) was measured using an inflatable jacket technique.
Main Results:
- Histamine inhalation generally led to small increases in FRC below the provoking concentration (PC).
- Significant increases in FRC were observed at the PC.
- Observed FRC changes suggested potential underestimation of airflow reduction.
Conclusions:
- Histamine challenge can alter FRC in wheezy infants.
- Changes in FRC may influence the interpretation of airflow limitation measurements.
- Further investigation is needed to understand the implications of FRC alterations in pediatric respiratory assessments.