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Polyhydrazide-Based Organic Nanotubes as Efficient and Selective Artificial Iodide Channels.

Arundhati Roy1, Himanshu Joshi2, Ruijuan Ye3

  • 1NanoBio Lab, 31 Biopolis Way, The Nanos, Singapore, 138669, Singapore.

Angewandte Chemie (International Ed. in English)
|January 18, 2020
PubMed
Summary

New polymeric nanotubes efficiently transport anions, like iodide, across cell membranes. These novel channels show high selectivity and function even in cholesterol-rich environments, offering potential for targeted ion transport applications.

Keywords:
hydrogen bondsiodideion channelsmolecular dynamicssupramolecular chemistry

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biophysics

Background:

  • Developing synthetic channels for selective ion transport across lipid membranes is crucial for understanding biological processes and creating artificial membrane systems.
  • Polymeric nanotubes offer a promising scaffold for creating stable and tunable transmembrane pores.

Purpose of the Study:

  • To synthesize and characterize novel pore-containing polymeric nanotubes based on a hydrogen-bonded hydrazide backbone.
  • To investigate the ion transport capabilities and selectivity of these nanotubes across lipid membranes.
  • To elucidate the structural basis for anion selectivity using molecular dynamics simulations.

Main Methods:

  • Synthesis of pore-containing polymeric nanotubes with a hydrazide backbone.
  • Lipid bilayer reconstitution assays to study ion transport.
  • Measurement of anion and cation transport efficiency using techniques like EC50 determination.
  • Molecular dynamics simulations to analyze channel structure and ion selectivity.

Main Results:

  • The synthesized nanotubes possess a hollow cavity of approximately 6.5 Å diameter and exhibit efficient transport of various anions, but not cations.
  • Iodide transport was particularly efficient (EC50 = 0.042 μm), significantly outperforming chloride transport (EC50 = 0.47 μm).
  • High anion transport activity, especially for iodide, was maintained even in cholesterol-rich membrane environments.
  • Molecular dynamics simulations confirmed high anion selectivity, attributed to the positive electrostatic potential of the nanotube lumen.

Conclusions:

  • Hydrogen-bonded polymeric nanotubes can serve as efficient and selective anion transporters across lipid membranes.
  • The structural features, including interior-pointing methyl groups, are key to achieving high anion selectivity.
  • These findings present a novel platform for artificial anion channels with potential applications in sensing and therapeutics.