Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Problem Solving on Stress and Strain

Problem Solving on Stress and Strain

Stress is a quantity that describes the magnitude of a force that causes deformation, generally defined as internal force per unit area. When forces pull on an object and cause its elongation, like the stretching of an elastic band, it is called tensile stress. When forces cause the compression of an object, it is known as compressive stress. When an object is being squeezed uniformly from all sides, like a submarine in the depths of the ocean, we call this kind of stress bulk stress (or volume...

Elastic Strain Energy for Shearing Stresses

Elastic Strain Energy for Shearing Stresses

As discussed in previous lessons, strain energy in a material is the energy stored when it is elastically deformed, a concept crucial in materials science and mechanical engineering. This energy results from the internal work done against the cohesive forces within the material. When a material undergoes shearing stress and corresponding shearing strain, the strain energy density, which is the energy stored per unit volume, is calculated. Within the elastic limit, where the stress is...

Dynamic Modulus of Elasticity of Concrete

Dynamic Modulus of Elasticity of Concrete

The dynamic modulus of elasticity assesses how a concrete structure deforms under impact or dynamic loads. It is typically higher than the static modulus of elasticity, measured under slow, steady loading conditions.
The sonic test is a common method to determine the dynamic modulus. In this test, a concrete beam, sized either 6 x 6 x 30 inches or 4 x 4 x 20 inches, is clamped at its center. Vibrations are initiated at one end of the beam by an electromagnetic exciter unit powered by a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Impact of physiological strain on lung epithelial cells by exposure to aerosolised quartz silica in a perfused bioreactor.

Frontiers in bioengineering and biotechnology·2026

Same author

New Hyaluronic Acid-Based Bioengineered 3D Scaffold: Fabrication and Potential for Oocyte In Vitro Maturation.

Biotechnology and bioengineering·2026

Same author

International Forum on Visceral Myopathy 2024: Advances in the Knowledge of the Disease.

Neurogastroenterology and motility·2026

Same author

Engineering a smart intrauterine device based on pH-controlled copper release.

Bioengineering & translational medicine·2025

Same author

Precision design of dextran-permeated agarose hydrogels matching adipose stem cell adhesion timescales.

Materials today. Bio·2025

Same author

Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers.

Pharmaceutics·2024

Same journal

Correction: Yang et al. Microstructural Characteristics of High-Pressure Die Casting with High Strength-Ductility Synergy Properties: A Review. <i>Materials</i> 2023, <i>16</i>, 1954.

Materials (Basel, Switzerland)·2026

Same journal

Effect of La and Ce Microalloying on the Corrosion Resistance of 0.4Sb Low-Alloy Steel in a Harsh Marine Atmospheric Environment.

Materials (Basel, Switzerland)·2026

Same journal

High-Temperature Properties of Magnesium Ammonium Phosphate Cement Modified with Gold Tailings.

Materials (Basel, Switzerland)·2026

Same journal

A Study on the Evolution of Intermetallic Phase Microstructure and High-Temperature Creep Behavior in Mg-8.0Al-1.0Nd-1.5Gd-Mn Alloys.

Materials (Basel, Switzerland)·2026

Same journal

Material-Driven Clinical Complications in Mechanical Circulatory Support: From Blood-Material Interactions to Device-Related Adverse Events.

Materials (Basel, Switzerland)·2026

Same journal

Influence of Final Irrigation on Calcium Silicate-Based Sealer Dentinal Tubular Penetration: A Systematic Review.

Materials (Basel, Switzerland)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 30, 2025

Characterizing Dissipative Elastic Metamaterials Produced by Additive Manufacturing

Characterizing Dissipative Elastic Metamaterials Produced by Additive Manufacturing

Published on: June 28, 2024

Engineering Gels with Time-Evolving Viscoelasticity.

Giorgio Mattei¹, Ludovica Cacopardo², And Arti Ahluwalia^1,2

¹Department of Information Engineering, University of Pisa, Via Girolamo Caruso 16, 56122 Pisa, Italy.

Materials (Basel, Switzerland)

|January 23, 2020

Summary

This summary is machine-generated.

Researchers developed dynamic viscoelastic substrates that change mechanical properties over time. This biomaterial innovation allows for studying cell adaptation to evolving mechanical microenvironments, advancing mechanobiology research.

Keywords:

ageing dynamic mechanical properties transglutaminase viscoelasticity

More Related Videos

The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton

The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton

Published on: March 10, 2023

Evaluation of the Curing of Adhesive Systems by Rheological and Thermal Testing

Evaluation of the Curing of Adhesive Systems by Rheological and Thermal Testing

Published on: July 3, 2020

Related Experiment Videos

Last Updated: Dec 30, 2025

Characterizing Dissipative Elastic Metamaterials Produced by Additive Manufacturing

Characterizing Dissipative Elastic Metamaterials Produced by Additive Manufacturing

Published on: June 28, 2024

The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton

The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton

Published on: March 10, 2023

Evaluation of the Curing of Adhesive Systems by Rheological and Thermal Testing

Evaluation of the Curing of Adhesive Systems by Rheological and Thermal Testing

Published on: July 3, 2020

Area of Science:

Biomaterials Science
Cellular Mechanobiology
Tissue Engineering

Background:

Native extracellular matrix (ECM) exhibits dynamic viscoelastic properties that change with physiological processes like aging.
Current biomaterial research primarily focuses on static stiffness, with limited exploration of time- or space-dependent substrate mechanics.

Purpose of the Study:

To engineer dynamic viscoelastic substrates with time-evolving mechanical properties.
To provide a tool for investigating cellular responses to dynamic mechanical microenvironments.
To understand cell adaptation to temporal variations in substrate mechanics.

Main Methods:

A two-step crosslinking strategy using glutaraldehyde and microbial transglutaminase was employed to modulate gelatin hydrogel properties.
Glutaraldehyde concentration was varied to mimic diverse soft tissue viscoelastic behaviors.
Microbial transglutaminase was used to induce time-dependent mechanical alterations in the hydrogels.

Main Results:

The engineered hydrogels demonstrated tunable viscoelastic parameters that evolved over time.
Enzymatically induced mechanical changes occurred within 24 hours, with a decreased time constant and stable elastic properties for up to seven days.
Preliminary cell culture studies confirmed cell adhesion and viability on the dynamic substrates.

Conclusions:

The developed method enables the creation of dynamic viscoelastic substrates with controlled temporal mechanical changes.
These substrates serve as a valuable tool for studying cell behavior and adaptation in response to evolving mechanical cues.
This approach advances the field of mechanobiology by enabling research into dynamic cell-microenvironment interactions.