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Updated: Dec 30, 2025

Chromatin Isolation by RNA Purification ChIRP
Published on: March 25, 2012
Centromeric Non-Coding RNAs: Conservation and Diversity in Function
1Department of Biological Sciences, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto 860-8555, Japan.
Abstract:
Chromosome segregation is strictly regulated for the proper distribution of genetic material to daughter cells. During this process, mitotic chromosomes are pulled to both poles by bundles of microtubules attached to kinetochores that are assembled on the chromosomes. Centromeres are specific regions where kinetochores assemble. Although these regions were previously considered to be silent, some experimental studies have demonstrated that transcription occurs in these regions to generate non-coding RNAs (ncRNAs). These centromeric ncRNAs (cenRNAs) are involved in centromere functions. Here, we describe the currently available information on the functions of cenRNAs in several species.
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