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Microtubules in Polyomavirus Infection
Lenka Horníková1, Kateřina Bruštíková1, Jitka Forstová1
1Department of Genetics and Microbiology, Faculty of Science, Charles University, BIOCEV, 25250 Postal code Vestec, Czech Republic.
Viruses
|January 23, 2020
Summary
Polyomaviruses hijack cellular microtubules for transport and replication. Viral proteins manipulate microtubule dynamics, impacting cell division and infection progression.
Area of Science:
- Cell Biology
- Virology
- Cytoskeleton Dynamics
Background:
- Microtubules are essential cytoskeletal components involved in intracellular transport, cell division, and polarity.
- Microtubules play a significant role in the life cycle of various viruses, including polyomaviruses.
Purpose of the Study:
- To review the critical role of the microtubule network in polyomavirus infection.
- To elucidate how polyomaviruses interact with and manipulate microtubules for their replication.
Main Methods:
- Review of existing literature on polyomavirus-microtubule interactions.
- Analysis of viral protein functions (T antigens, VP1) in modulating microtubule dynamics.
Main Results:
- Polyomaviruses utilize microtubules and motor proteins (kinesin-1, dynein) for intracellular trafficking from endosomes to the endoplasmic reticulum and then to the nucleus.
- Early viral proteins (T antigens) destabilize microtubules, leading to aberrant mitosis and potential tumorigenesis.
- The major capsid protein (VP1) of mouse polyomavirus stabilizes microtubules, inducing a G2/M cell cycle block essential for viral replication.
Conclusions:
- Microtubules are crucial for polyomavirus entry, intracellular transport, and replication.
- Viral manipulation of microtubule dynamics is a key strategy for successful polyomavirus infection and potentially tumorigenesis.
Keywords:
T antigensVP1 capsid proteincell cycle blockdyneinkinesinmicrotubulesmolecular motorspolyomavirusvirusvirus traffickingMore Related Videos
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