Low-cost management of mushroom poisoning in a limited-resource area: a 12-year retrospective study
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Updated: Dec 30, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Ratsameekhae Jongthun1, Pasin Hemachudha2, Supaporn Wacharapluesadee3
1Internal medicine consultant, Department of Internal Medicine, Loei Hospital, Loei Province, Thailand.
Abstract:
Amatoxin poisoning is the main cause of death from accidental ingestion of poisonous mushrooms and a mortality rate of 27.3% has been reported in Thailand. Symptoms of mushroom ingestion are often confused with food poisoning; thus, gastroenteritis is not recognised as the first phase of poisoning. Our study assessed the efficacy of N-acetylcysteine (NAC) as a treatment for amatoxin poisoning. We retrospectively analysed 74 medical records over 12 years. The majority (70/74) were treated successfully with NAC; death in the remaining 4 (5.4%) patients was attributed to late presentation in three and advanced alcoholic cirrhosis in one.
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