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Updated: Dec 30, 2025
DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
Published on: December 29, 2021
A self-powered 3D DNA walker with programmability and signal-amplification for illuminating microRNA in living cells
Xue-Jiao Yang1, Mei-Rong Cui1, Xiang-Ling Li1
1State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China. xlli@nju.edu.cn xujj@nju.edu.cn.
Abstract:
Based on the structural programmability and spatial addressability of DNA nanodevices, a target-triggered, enzyme-free 3D DNA walker, comprising of hairpin DNA assembled gold nanoparticles with a local catalytic hairpin assembly reaction, was developed for the highly sensitive detection of intracellular tumor-associated microRNAs.
