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Analysis of SEC-SAXS data via EFA deconvolution and Scatter
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Request for an Andexxa Value Analysis.

Ellen Yin1, Karen J McConnell2

  • 1Catholic Health Initiatives, Houston, TX, USA.

The Annals of Pharmacotherapy
|January 24, 2020
PubMed
Summary
This summary is machine-generated.

This perspective urges the American College of Cardiology and American Heart Association to analyze the value of andexanet alfa, a costly drug with safety and efficacy concerns. A formal value statement is needed to guide its use amid rising healthcare expenses.

Keywords:
andexanetanticoagulationapixabandirect oral anticoagulant reversalprothrombin complex concentraterivaroxabanvalue analysis

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Area of Science:

  • Cardiovascular Medicine
  • Health Economics
  • Pharmacoeconomics

Background:

  • Andexanet alfa (Andexxa) is a reversal agent for direct oral anticoagulants.
  • Concerns regarding the safety and efficacy of andexanet alfa exist.
  • The high cost of andexanet alfa necessitates a thorough value assessment.

Purpose of the Study:

  • To formally request the American College of Cardiology and American Heart Association (ACC/AHA) to conduct a value analysis of andexanet alfa.
  • To advocate for a value statement or guideline addendum regarding andexanet alfa.
  • To promote responsible stewardship of healthcare resources.

Main Methods:

  • This is a perspective piece, not a research study.
  • It proposes a value analysis framework similar to that used for PCSK9 inhibitors.
  • The analysis would consider safety, efficacy, and cost-effectiveness.

Main Results:

  • A formal value analysis and statement are currently lacking for andexanet alfa.
  • The high cost and existing concerns highlight the need for such an analysis.
  • Such a statement would aid clinicians, health systems, and payers in decision-making.

Conclusions:

  • A comprehensive value analysis of andexanet alfa by the ACC/AHA is crucial.
  • A society guideline addendum or value statement is vital for appropriate use.
  • Responsible resource allocation in healthcare requires careful evaluation of high-cost therapies.