Cocaine detection using aptamer and molybdenum disulfide-gold nanoparticle-based sensors

Aim: The current work highlighted a novel colorimetric sensor based on aptamer and molybdenum disulfide (MoS₂)-gold nanoparticles (AuNPs) that was developed for cocaine detection with high sensitivity. Materials & methods: Due to the presence of the plasmon resonance band on the surface of AuNPs, AuNPs aggregated and the color was changed from red to blue after adding a certain concentration of NaCl. We used MoS₂ to optimize the sensing system of AuNPs. The folded conformation of the aptamer in combination with cocaine enhanced the salt tolerance of the MoS₂-AuNPs, effectively preventing their aggregation. Results & conclusion: The detection limit of cocaine was 7.49 nM with good selectivity. The method based on MoS₂-AuNPs colorimetry sensor is simple, quick, label-free and low cost.