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Detection of O4-ethylthymine in human liver DNA

N Huh¹, M S Satoh, J Shiga

¹Department of Cancer Cell Research, University of Tokyo, Japan.

IARC Scientific Publications

|January 1, 1988

Abstract:

O4-Ethyl-2'-deoxythymidine (O4-EtdThy) in human liver DNA was quantified, in order to monitor possible human exposure to ethylating agents, using a highly sensitive immunological detection method. In 30 of 33 cases analysed, O4-EtdThy was detected at above the detection limit (i.e., 3 x 10(-8) O4-EtdThy/2'-deoxy-thymidine[dThy]), indicating actual chronic exposure to ethylating agents. The mean content of O4-EtdThy in 19 cases of malignant tumours was significantly higher than that in 11 nonmalignant cases (p less than 0.05).

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