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Peripheral neuropathy in hematologic malignancies - Past, present and future.
Tiffany Li1, Hannah C Timmins1, Hillard M Lazarus2
1Brain and Mind Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.
Blood Reviews
|January 28, 2020
Summary
Peripheral neuropathy is a common side effect of neurotoxic cancer treatments for hematologic malignancies. This review updates risk factors, mechanisms, and treatments for this debilitating nerve condition.
Area of Science:
- Oncology
- Neurology
- Pharmacology
Background:
- Neurotoxic treatments are integral to hematologic malignancy management.
- Peripheral neuropathy (PN) is a frequent complication, arising from the disease or its treatment.
- PN manifests as sensory, motor, or autonomic dysfunction, causing pain and disability.
Purpose of the Study:
- To provide an updated review of peripheral neuropathy in hematologic malignancy.
- To examine clinical features, risk factors, and mechanisms of PN associated with specific neurotoxic agents.
- To discuss current and future treatment strategies, including pharmacogenetic considerations.
Main Methods:
- Literature review of studies on peripheral neuropathy in hematologic malignancy.
- Analysis of clinical data and risk factors for PN related to bortezomib, thalidomide, brentuximab vedotin, and vinca alkaloids.
- Review of pharmacogenetic data and potential therapeutic interventions.
Main Results:
- Identified key risk factors and clinical presentations of PN for common neurotoxic agents.
- Highlighted the role of both disease-related and treatment-related factors in PN development.
- Summarized current understanding of PN mechanisms and explored emerging treatment options.
Conclusions:
- Peripheral neuropathy is a significant challenge in hematologic malignancy care, necessitating careful monitoring and management.
- Understanding pharmacogenetic factors may allow for personalized risk assessment and prevention strategies.
- Further research is crucial to optimize treatment and minimize the impact of PN on patients' quality of life.
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