Related Experiment Video
Updated: Dec 30, 2025
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
Published on: February 19, 2021
Interreader Agreement of Liver Imaging Reporting and Data System on MRI: A Systematic Review and Meta-Analysis
Ji Hun Kang1, Sang Hyun Choi1, Ji Sung Lee2,3
1Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Background:
Use of the Liver Imaging Reporting and Data System (LI-RADS) is increasing, but the reported results for interreader agreement seem quite variable.
Purpose:
To systematically determine the interreader agreement of LI-RADS on magnetic resonance imaging (MRI) and to determine the sources of heterogeneity between the reported results.
Study Type:
Systematic review and meta-analysis.
Subjects:
Fifteen original articles with 2968 lesions.
Field Strength:
1.5T and 3.0T.
Assessment:
Two reviewers independently performed the data extraction. The reviewers identified and reviewed the original articles reporting the interreader agreement of LI-RADS using MRI.
Statistical Tests:
The meta-analytic pooled intraclass correlation coefficient (ICC) for lesion size and kappa value (κ) for major features (arterial-phase hyperenhancement [APHE], nonperipheral washout [WO], enhancing capsule [EC]) and LI-RADS categorization (LR) were calculated using the random-effects model. Sensitivity analysis and meta-regression analysis were performed to explore the cause of study heterogeneity.
Results:
The meta-analytic pooled ICC of lesion size was 0.97 (95% confidence interval [CI], 0.94-1.00). Meta-analytic pooled κ of APHE, WO, EC, and LR were 0.72 (95% CI, 0.62-0.82), 0.69 (95% CI, 0.60-0.78), 0.66 (95% CI, 0.58-0.74), and 0.70 (95% CI, 0.56-0.85), respectively. Substantial study heterogeneity was noted in all five variables (I2 ≥ 89.1%, P < 0.001). Study design, type, and clarity of blinding review were factors that significantly influenced study heterogeneity (P ≤ 0.05).
Data Conclusion:
LI-RADS demonstrated overall substantial interreader agreement for major features and the category on MRI, but showed heterogeneous results between studies.
Level Of Evidence:
3 TECHNICAL EFFICACY STAGE: 2 J. Magn. Reson. Imaging 2020;52:795-804.
Related Concept Videos
01:21Imaging Studies for Cardiovascular System IV: CMRI
01:24Magnetic Resonance Imaging
01:27Imaging Studies IV: Magnetic Resonance Imaging
01:14Imaging Studies I: CT and MRI
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
01:30Radiological Investigation II: MRI and Ventilation Perfusion Scan
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...