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Post-translational modification of baculovirus-encoded proteins
Nan Chen1, Xiangshuo Kong1, Shudi Zhao1
1College of animal sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.
Virus Research
|January 29, 2020
Summary
This review summarizes post-translational modifications (PTMs) in baculoviruses, focusing on AcMNPV and BmNPV. It highlights the importance of PTMs for viral protein function and biological processes.
Area of Science:
- Virology
- Molecular Biology
- Biochemistry
Background:
- Post-translational modifications (PTMs) are crucial for protein function.
- Baculoviruses are DNA viruses that infect invertebrates.
- PTMs like phosphorylation and glycosylation occur in baculovirus proteins.
Purpose of the Study:
- To provide a comprehensive overview of reported PTMs in baculoviruses.
- To consolidate existing knowledge on baculovirus protein modifications.
- To focus on PTMs in Autographa californica multiple nucleopolyhedrovirus (AcMNPV) and Bombyx mori nucleopolyhedrovirus (BmNPV).
Main Methods:
- Literature review of studies on baculovirus PTMs.
- Compilation of reported PTMs across various baculovirus proteins.
- Focus on PTMs identified in AcMNPV and BmNPV.
Main Results:
- Baculovirus proteins undergo diverse PTMs, including phosphorylation, glycosylation, ubiquitination, and acetylation.
- A significant number of baculovirus-encoded proteins are subject to these modifications.
- The review consolidates information previously scattered across numerous studies.
Conclusions:
- PTMs play a vital role in baculovirus biology and infection.
- This review serves as a foundational resource for understanding baculovirus PTMs.
- Further research into specific PTMs can reveal novel insights into baculovirus pathogenesis and replication.
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