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Quantitative and Morphological Corneal Endothelial Changes After Selective Laser Trabeculoplasty and Retinal
Aran Kanagaratnam1,2, Keith Ong1,2
1Department of Ophthalmology, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
Asia-Pacific Journal of Ophthalmology (Philadelphia, Pa.)
|January 29, 2020
Summary
Selective laser trabeculoplasty (SLT) and retinal photocoagulation (RP) have minor, transient effects on the corneal endothelium. Corneal specular microscopy showed SLT caused slight cell count reduction and morphological changes, while RP only affected polymegathism, with both unlikely to be clinically significant.
Area of Science:
- Ophthalmology
- Corneal Science
- Laser Procedures
Background:
- Selective laser trabeculoplasty (SLT) and retinal photocoagulation (RP) are common ophthalmic laser treatments.
- Both procedures utilize a 532 nm wavelength and may potentially impact the corneal endothelium.
Purpose of the Study:
- To investigate the effects of SLT and RP on the corneal endothelium.
- Utilize corneal specular microscopy to assess quantitative and morphological changes.
Main Methods:
- Retrospective cohort study involving 249 eyes (SLT) and 132 eyes (RP).
- Corneal specular microscopy performed pre-procedure, post-procedure, and at 1-month follow-up.
- Evaluated cell density, central corneal thickness, hexagonal cell percentage, and cell area variation.
Main Results:
- SLT showed a transient 1% decrease in endothelial cell count and minor morphological changes (pleomorphism).
- Central corneal thickness transiently increased post-SLT.
- RP resulted in a statistically significant increase in polymegathism.
Conclusions:
- SLT induces transient, minor quantitative and morphological changes in the corneal endothelium.
- RP has fewer observed effects, potentially due to longer laser pulse duration.
- Observed changes in both procedures are unlikely to be clinically significant for patients.
