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Sensitive Readout for Microfluidic High-Throughput Applications using Scanning SQUID Microscopy.

Shai Wissberg1,2, Maria Ronen2,3, Ziv Oren3,4

  • 1Department of Physics, Bar-Ilan University, Ramat-Gan, 52900, Israel.

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Summary

This study introduces a novel microfluidic-scanning SQUID microscopy technique for highly sensitive detection of protein-protein interactions (PPI). It achieves 0.1 atto-mole sensitivity, outperforming conventional methods.

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Area of Science:

  • Biophysics
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Microfluidic chips are crucial for high-throughput screening, but current fluorescence-based detection has limitations in low signal quantification.
  • Developing novel readout techniques for microfluidics is essential for advancing quantitative biophysical analysis.

Purpose of the Study:

  • To develop and validate a new quantitative readout technique for microfluidic systems.
  • To integrate magnetic nanoparticles and a scanning superconducting quantum interference device (SQUID) microscope for enhanced sensitivity.
  • To demonstrate the application of this technique for studying protein-protein interactions (PPI).

Main Methods:

  • Combining immunoassay with magnetic nanoparticles within a microfluidic array.
  • Utilizing a scanning SQUID microscope to image nanoparticle movement through the microfluidic device.
  • Quantifying protein-protein interactions and comparing sensitivity against conventional methods.

Main Results:

  • Demonstrated a novel microfluidic-scanning SQUID microscopy technique.
  • Achieved a sensitivity of 0.1 atto-moles for protein-protein interactions.
  • Showcased quantitative analysis capabilities in the low signal regime.

Conclusions:

  • The developed technique offers a powerful new tool for sensitive and quantitative analysis in microfluidic systems.
  • This proof-of-concept study paves the way for stable and usable microfluidic-scanning SQUID microscopy.
  • The method significantly enhances detection capabilities for biophysical screening, particularly for protein-protein interactions.