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Related Experiment Video

Updated: Jan 18, 2026

A Microfluidic Platform for Longitudinal Imaging in Caenorhabditis elegans
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A Microfluidic Platform for Longitudinal Imaging in Caenorhabditis elegans

Published on: May 2, 2018

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Integrated Microfluidic Platform for Longitudinal Imaging, Functional Assays, and Downstream Proteomics in C.

Noa Marchoom-Bura1,2, Shira Zelikman1,2, David Morgenstern3

  • 1The Mina & Everard Goodman Faculty of Life Sciences, Bar Ilan University, Anna and Max Webb 1, Ramat-Gan, 5230002, Israel.

Small (Weinheim an Der Bergstrasse, Germany)
|September 12, 2025
PubMed
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This study introduces a microfluidic platform for long-term, high-content imaging of Caenorhabditis elegans (C. elegans). The system enables non-invasive monitoring from larvae to adulthood, integrating feeding, waste removal, and proteomics.

Area of Science:

  • Developmental Biology
  • Neurobiology
  • Host-Pathogen Interactions

Background:

  • Caenorhabditis elegans (C. elegans) is a key model organism.
  • Current imaging methods for C. elegans cause stress and are fragmented.
  • Need for integrated, non-invasive long-term imaging solutions.

Purpose of the Study:

  • To develop an integrated microfluidic platform for continuous, high-resolution imaging of individual C. elegans.
  • To enable seamless monitoring from larval stages to adulthood.
  • To support diverse applications including physiological assays, infection models, and proteomics.

Main Methods:

  • A microfluidic device with dynamic fluidic control for automated feeding, waste, and progeny removal.
  • Transient, non-invasive immobilization of up to 20 worms in parallel.
Keywords:
C. elegansfunctional assaysintegrated microfluidicsproteomics

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  • Integration of reporter strains (sod-3p::GFP), pathogen tracking, and single-nematode proteomics.

    • Main Results:

    • The platform supports continuous imaging from L1 larvae to adulthood.
    • Short-term immobilization showed no detectable stress; starvation induced strong stress response.
    • Real-time pathogen tracking and identification of over 80 C. elegans proteins from single worms were achieved.

    Conclusions:

    • The microfluidic system provides a powerful tool for integrated, single-organism resolution studies in C. elegans.
    • It overcomes limitations of existing methods, enabling advanced functional biology research.
    • Facilitates seamless integration of developmental monitoring, physiological assays, infection models, and molecular profiling.