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Updated: Dec 29, 2025

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
New Horizons for Molecular Genetics Diagnostic and Research in Autism Spectrum Disorder
Nader Al-Dewik1,2,3,4, Mohammed Alsharshani5
1Clinical and Metabolic Genetics Section, Pediatrics Department, Hamad General Hospital (HGH) and Women's Wellness and Research Center (WWRC), Doha, Qatar. naldewik@hamad.qa.
Abstract:
Autism spectrum disorder (ASD) is a highly heritable, heterogeneous, and complex pervasive neurodevelopmental disorder (PND) characterized by distinctive abnormalities of human cognitive functions, social interaction, and speech development.Nowadays, several genetic changes including chromosome abnormalities, genetic variations, transcriptional epigenetics, and noncoding RNA have been identified in ASD. However, the association between these genetic modifications and ASDs has not been confirmed yet.The aim of this review is to summarize the key findings in ASD from genetic viewpoint that have been identified from the last few decades of genetic and molecular research.
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