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Updated: Dec 29, 2025
05:47
Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
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Evidence based medicine - decades later.
Alex C Vidaeff1, Mark A Turrentine1, Michael A Belfort1
1Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.
Summary
Evidence-based medicine (EBM) implementation varies widely. We propose EBM is evolving towards personalized, contextualized care, integrating clinical expertise with evidence for better patient outcomes.
Area of Science:
- Medical Practice
- Clinical Decision Making
- Healthcare Systems
Background:
- Evidence-based medicine (EBM) has been widely embraced for over 20 years.
- Significant variation in EBM implementation persists globally.
- Concerns exist that EBM may be an ineffective model due to implementation challenges.
Purpose of the Study:
- To propose an evolved model of evidence-based medicine.
- To highlight the shift from a formulaic approach to a personalized, integrated, and contextualized method.
- To emphasize the importance of shared decision-making in modern healthcare.
Main Methods:
- Conceptual analysis of the evolution of evidence-based medicine.
- Integration of principles from shared decision-making frameworks.
- Discussion of the role of clinical expertise alongside general evidence.
Main Results:
- Evidence-based medicine is transitioning from a rigid protocol to a flexible, patient-centered approach.
- The integration of personalized patient factors is crucial for effective EBM.
- Shared decision-making principles are becoming central to applying evidence in practice.
Conclusions:
- Evidence-based medicine is not a failed model but an evolving one.
- Clinical expertise and practical wisdom are essential for applying evidence to individual patient needs.
- The future of EBM lies in its personalized, integrated, and contextualized application, guided by shared decision-making.
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