Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

5.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.6K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.1K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.1K
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

2.9K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.9K
Cancer Therapies02:49

Cancer Therapies

9.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.7K
Tumor Immunotherapy01:27

Tumor Immunotherapy

1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disease Activity-Related Sleep Dysfunction in Psoriasis: Insights from a Cross-Sectional Study.

Journal of clinical medicine·2026
Same author

Italian Translation, Cultural Adaptation and Clinical Application of the ACNE-Q: Patient-Reported Outcome Measure in Mild-to-Moderate Facial Acne.

Aesthetic plastic surgery·2026
Same author

Line-field Confocal Optical Coherence Tomography (LC-OCT) for Monitoring Tumor Clearance in Basal Cell Carcinoma After Cryotherapy.

Dermatology practical & conceptual·2026
Same author

Toward a New Classification of Lentigo Maligna: Easy and Difficult to Treat Lentigo Maligna.

Dermatology practical & conceptual·2026
Same author

Nasal Reconstruction After Skin Cancer Excision: Clinical and Patient-Reported Outcomes from a Retrospective Study.

Journal of clinical medicine·2026
Same author

International Dermoscopy Society consensus recommendations for the management of lentigo maligna.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026

Related Experiment Video

Updated: Dec 29, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.4K

Current therapies for actinic keratosis.

Caterina Dianzani1, Claudio Conforti2, Roberta Giuffrida3

  • 1Department of Plastic, Reconstructive and Cosmetic Surgery, Campus Bio-Medico University Hospital, Rome, Italy.

International Journal of Dermatology
|February 4, 2020
PubMed
Summary

Actinic keratosis (AK), a precursor to squamous cell carcinoma (SCC), requires treatment to eliminate lesions and prevent progression. This review details lesion-directed and field-directed therapies to guide optimal patient management.

More Related Videos

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
03:47

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application

Published on: September 27, 2024

1.4K
Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

1.5K

Related Experiment Videos

Last Updated: Dec 29, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.4K
Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
03:47

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application

Published on: September 27, 2024

1.4K
Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

1.5K

Area of Science:

  • Dermatology
  • Oncology

Background:

  • Actinic keratosis (AK) is a common skin condition resulting from chronic sun exposure.
  • AKs are considered an early stage of squamous cell carcinoma (SCC) due to their potential for malignant transformation.
  • Effective treatment and clinical follow-up are crucial for managing AK and preventing SCC development.

Purpose of the Study:

  • To review and compare various treatment options for actinic keratosis.
  • To outline the aims of AK treatment, including lesion eradication, SCC prevention, and relapse reduction.
  • To guide clinicians in selecting the most appropriate therapeutic approach for actinic keratosis.

Main Methods:

  • This review categorizes treatments into lesion-directed and field-directed therapies.
  • Lesion-directed treatments discussed include cryotherapy, laser therapy, surgery, and curettage.
  • Field-directed treatments examined include 5-fluorouracil (5-FU), diclofenac 3% gel, chemical peeling, imiquimod, and photodynamic therapy (PDT).

Main Results:

  • The review presents diverse treatment modalities for actinic keratosis.
  • Characteristics and benefits of each therapeutic option are described.
  • The review aims to identify the optimal treatment choice based on individual patient needs.

Conclusions:

  • Actinic keratosis management involves addressing both existing lesions and the surrounding skin field.
  • A combination of therapeutic interventions and preventative measures, such as sun protection, is recommended.
  • Personalized treatment strategies are essential for effectively managing AK and reducing SCC risk.