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Design and Development of Lomustine Loaded Chitosan Nanoparticles for Efficient Brain Targeting
Anupriya Anand1, Bharadhwaj Ramesh Iyer1, Chandrasekar Ponnusamy2
1SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chennai, India.
Cardiovascular & Hematological Agents in Medicinal Chemistry
|February 5, 2020
Summary
Optimized lomustine-loaded chitosan nanoparticles (LNCp) were prepared using ionic gelation. These nanoparticles show potential for brain targeting and further clinical applications.
Area of Science:
- Nanotechnology
- Materials Science
- Pharmaceutical Sciences
Background:
- Lomustine is an important chemotherapeutic agent.
- Developing effective drug delivery systems is crucial for improving therapeutic outcomes.
Purpose of the Study:
- To prepare and optimize lomustine-loaded chitosan nanoparticles (LNCp) using the Box-Behnken design.
- To evaluate the physicochemical properties and in-vitro drug release of LNCp.
- To assess the potential of LNCp for brain targeting.
Main Methods:
- Ionic gelation with homogenization for LNCp preparation.
- Box-Behnken design for experimental optimization.
- Characterization including particle size, zeta potential, surface morphology, drug content, and entrapment efficiency.
- In-vitro drug release studies.
Main Results:
- FT-IR confirmed no drug-excipient interaction.
- Optimized LNCp exhibited particle size between 190-255 nm, drug content of 80.88-94.02%, and entrapment efficiency of 77.12-88.74%.
- Drug release was diffusion-controlled over 8 hours, with statistically significant models (p < 0.05).
Conclusions:
- Optimized LNCp are suitable for brain targeting.
- The developed nanoparticles hold significant potential for future research and clinical applications in chemotherapy.
