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Serum amphotericin-B assay by scanning spectrophotometer
Z K Shihabi1, B L Wasilauskas, J E Peacock
1Department of Pathology, Wake Forest University, Bowman Gray School of Medicine, Winston-Salem, North Carolina.
Therapeutic Drug Monitoring
|January 1, 1988
Abstract:
We describe a simple, specific, 3-min assay for amphotericin-B in serum based on the absorbance at 408 nm and spectral scanning between 450 and 350 nm of the drug in acetonitrile extracts. The method correlated well with a high-performance liquid chromatographic method.