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Mismatch repair deficiency/microsatellite instability testing as predictive immunotherapy biomarkers-possible

Ioanna Gazouli1,2, George Zarkavelis1,2, Davide Mauri1,2

  • 1Department of Medical Oncology, University of Ioannina, Ioannina, Greece.

Annals of Translational Medicine
|February 5, 2020
PubMed
Summary

No abstract available in PubMed .

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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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