Related Experiment Video
Updated: Dec 29, 2025
Field Postmortem Rabies Rapid Immunochromatographic Diagnostic Test for Resource-Limited Settings with Further Molecular Applications
Published on: June 29, 2020
Diagnostic Testing for Crimean-Congo Hemorrhagic Fever
1Division of Infectious Diseases & Immunology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA vanessa.raabe@nyulangone.org.
Insights
Crimean-Congo hemorrhagic fever (CCHF) is a widespread tick-borne illness. Laboratory diagnostics are crucial for accurate diagnosis of CCHF in suspected human cases.
Area of Science:
- Virology
- Infectious Diseases
- Diagnostic Medicine
Background:
- Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne viral disease.
- It has the widest geographic distribution among tick-borne viruses.
- Mortality rates can reach up to 30%.
Purpose of the Study:
- To review available laboratory diagnostic tests for CCHF.
- To discuss the utility of these tests in diagnosing human CCHF cases.
- To focus on diagnostic approaches for CCHF in endemic regions.
Main Methods:
- Literature review of diagnostic methods for CCHF.
- Analysis of laboratory test performance and applicability.
- Focus on clinical utility in suspected human infections.
Main Results:
- Clinical diagnosis of CCHF is challenging due to non-specific symptoms.
- Laboratory diagnostics are essential for confirming CCHF.
- Various tests exist, each with specific applications in diagnosis.
Conclusions:
- Accurate laboratory testing is vital for CCHF diagnosis.
- Timely diagnosis improves patient outcomes and public health surveillance.
- Understanding available tests aids in managing CCHF in at-risk populations.
Abstract:
Crimean-Congo hemorrhagic fever is the most geographically widespread tick-borne virus, with infection resulting in mortality in up to 30% of cases. Clinical diagnosis alone is difficult due to the nonspecific nature of symptoms; therefore, laboratory diagnostics should be utilized for patients with residence in or travel to regions of endemicity in whom the disease is suspected. This minireview provides an overview of laboratory tests available for Crimean-Congo hemorrhagic fever (CCHF) and their utility in diagnosis with a focus on diagnosing CCHF in humans.
