Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

10.8K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.8K
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

1.6K
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
1.6K
Next-generation Sequencing03:00

Next-generation Sequencing

97.4K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
97.4K
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

9.9K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
9.9K
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

1.1K
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
1.1K
Preclinical Development: Overview01:28

Preclinical Development: Overview

5.7K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extracting prime protein targets as possible drug candidates: machine learning evaluation.

Medical & biological engineering & computing·2023
Same author

Towards Effective Consensus Scoring in Structure-Based Virtual Screening.

Interdisciplinary sciences, computational life sciences·2022
Same author

To Affinity and Beyond: A Personal Reflection on the Design and Discovery of Drugs.

Molecules (Basel, Switzerland)·2022
Same author

West Nile Virus Vaccine Design by T Cell Epitope Selection: <i>In Silico</i> Analysis of Conservation, Functional Cross-Reactivity with the Human Genome, and Population Coverage.

Journal of immunology research·2020
Same author

Correction to: Computational assembly of a human Cytomegalovirus vaccine upon experimental epitope legacy.

BMC bioinformatics·2020
Same author

Computational assembly of a human Cytomegalovirus vaccine upon experimental epitope legacy.

BMC bioinformatics·2019
Same journal

Assessment of lower incisor position and symphysis dimensions among different skeletal patterns in the Chhattisgarh population.

Bioinformation·2026
Same journal

Low T3 syndrome and short-term outcomes in patients with acute decompensated heart failure: A retrospective observational study.

Bioinformation·2026
Same journal

Cardiovascular risk prevention awareness and practices in type 2 diabetes: Linking HbA1c and lipid levels.

Bioinformation·2026
Same journal

Assessment of periodontal condition using basic periodontal examination scores: A retrospective clinical study.

Bioinformation·2026
Same journal

Comparative evaluation of osseointegration among different surface modification techniques in dental implants.

Bioinformation·2026
Same journal

Micro-osteoperforations' impact on orthodontic tooth movement rate: Split mouth research.

Bioinformation·2026
See all related articles

Related Experiment Video

Updated: Dec 29, 2025

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
06:26

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

Published on: May 16, 2021

5.4K

Drug Discovery: Today and Tomorrow.

Darren R Flower1

  • 1Independent Interdisciplinary Consultant, Oxford, United Kingdom.

Bioinformation
|February 7, 2020
PubMed
Summary
This summary is machine-generated.

Drug discovery efforts fall short due to profit-driven motives and inadequate funding, hindering progress. Innovation requires systemic infrastructure changes, not just new technologies, to meet medical needs.

More Related Videos

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

10.1K
Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA
10:21

Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA

Published on: February 23, 2024

3.5K

Related Experiment Videos

Last Updated: Dec 29, 2025

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
06:26

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

Published on: May 16, 2021

5.4K
Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

10.1K
Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA
10:21

Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA

Published on: February 23, 2024

3.5K

Area of Science:

  • Pharmaceutical Sciences
  • Biotechnology
  • Medicinal Chemistry

Background:

  • Current drug discovery paradigms demonstrate suboptimal performance in addressing significant unmet medical needs.
  • The pharmaceutical industry's focus on profit over societal benefit results in insufficient funding and a lack of systematic approaches.
  • Existing drug discovery methodologies are fraught with challenges, limiting efficiency and success rates.

Discussion:

  • Innovative methodologies in drug discovery are underutilized, despite their potential to overcome current limitations.
  • Technical advancements alone are insufficient to revolutionize drug discovery without concurrent infrastructural improvements.
  • The current infrastructure supporting drug discovery is a major bottleneck, impeding the realization of scientific potential.

Key Insights:

  • Drug discovery's underperformance is linked to a profit-driven model rather than societal needs.
  • Systematic funding and methodological improvements are crucial for advancing pharmaceutical research.
  • Infrastructure reform is essential to unlock the full potential of novel drug discovery approaches.

Outlook:

  • Future drug discovery success hinges on aligning research priorities with societal needs and ensuring adequate, systematic funding.
  • Integrating underused innovative approaches into a reformed infrastructure is vital for accelerating therapeutic development.
  • A paradigm shift focusing on systemic change is necessary to enhance the efficiency and impact of drug discovery efforts.