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Antibacterial nanostructures derived from oxidized sodium alginate-ZnO
L M Dwivedi1, K Baranwal2, S Gupta2
1Department of Chemistry, University of Allahabad, Allahabad, 211002, Uttar Pradesh, India; Department of Biotechnology, University of Allahabad, Allahabad, 211002, Uttar Pradesh, India.
International Journal of Biological Macromolecules
|February 7, 2020
Summary
This study synthesized novel oxidized sodium alginate-zinc oxide (OSA-ZnO) nanostructures, demonstrating superior antibacterial activity against common pathogens compared to pure zinc oxide. The findings highlight OSA-ZnO as a promising antibacterial material.
Area of Science:
- Materials Science
- Nanotechnology
- Biotechnology
Background:
- Polysaccharide-based nanomaterials are increasingly explored for antibacterial applications.
- Understanding the influence of polysaccharide charge on material properties is crucial for developing effective antibacterial agents.
Purpose of the Study:
- To synthesize and characterize oxidized sodium alginate-zinc oxide (OSA-ZnO) hybrid nanostructures.
- To evaluate the antibacterial efficacy of OSA-ZnO against various bacterial strains.
- To investigate the role of polysaccharide charge in designing antibacterial materials.
Main Methods:
- Synthesis of OSA-ZnO hybrid nanostructures.
- Characterization using UV-visible, FTIR, XRD, SEM, and TEM analyses.
- Antibacterial activity testing against Bacillus subtilis, Cellulomonas cellulans, Staphylococcus typhi, and Escherichia coli.
Main Results:
- OSA-ZnO nanostructures exhibited a hexagonal crystalline phase with a particle size of approximately 6 nm.
- The synthesized nanostructures demonstrated significant antibacterial performance against all tested bacterial strains.
- OSA-ZnO showed enhanced antibacterial activity compared to pure ZnO, while native SA and OSA displayed no biological activity.
Conclusions:
- Oxidized sodium alginate-zinc oxide hybrid nanostructures are effective antibacterial agents.
- The charge characteristics of the polysaccharide significantly influence the antibacterial properties of the hybrid material.
- OSA-ZnO represents a promising candidate for developing advanced antibacterial materials.
