Association between thoracic fat measured using computed tomography and lung function in a population without
Won Gun Kwack1,2, Yun-Seong Kang1, Yun Jeong Jeong1
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, South Korea.
Journal of Thoracic Disease
|February 8, 2020
Summary
Thoracic adiposity impacts lung function differently in males and females. Increased visceral and subcutaneous fat in males, and subcutaneous fat in females, are linked to reduced lung capacity.
Area of Science:
- Cardiology
- Pulmonology
- Radiology
Background:
- Local fat distribution and its effects are gaining attention.
- Thoracic adiposity's impact on lung function is under investigation.
- Understanding sex-specific effects is crucial.
Purpose of the Study:
- To assess the impact of thoracic adiposity on lung function.
- To evaluate sex-specific differences in this association.
- To analyze various fat depots including pericardial, intrathoracic, and abdominal fat.
Main Methods:
- 455 subjects (282 males, 173 females) underwent spirometry and CT scans.
- Computed tomography measured pericardial, intrathoracic, subcutaneous thoracic, and abdominal fat volumes.
- Multiple linear regression analyses adjusted for smoking, HDL, and hs-CRP.
Main Results:
- In males, intrathoracic and visceral abdominal fat inversely correlated with FEV1% predicted.
- Subcutaneous thoracic fat negatively correlated with FEV1% and FVC% predicted in both sexes.
- Subcutaneous thoracic fat showed a negative correlation with FEV1% and FVC% predicted in females.
Conclusions:
- Sex influences the relationship between thoracic fat distribution and lung function.
- Visceral and subcutaneous thoracic fat in males, and subcutaneous fat in females, are linked to diminished lung function.
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