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Translational Landscape of mTOR Signaling in Integrating Cues Between Cancer and Tumor Microenvironment

Chiara Bazzichetto1, Fabiana Conciatori1, Italia Falcone1

  • 1Medical Oncology 1, IRCCS-Regina Elena National Cancer Institute, Rome, Italy.

Advances in Experimental Medicine and Biology
|February 8, 2020
PubMed

Insights

The mammalian target of rapamycin (mTOR) pathway regulates normal and tumor cell processes. Targeting mTOR shows promise for improving anti-cancer immune responses and long-term efficacy.

Area of Science:

  • Oncology
  • Cell Biology
  • Immunology

Background:

  • The mammalian target of rapamycin (mTOR) is a key regulator in normal and cancer cells.
  • mTOR integrates environmental signals within the tumor microenvironment (TME).

Purpose of the Study:

  • To elucidate the role of mTOR in modulating TME components.
  • To explore the implications of targeting mTOR for cancer therapy.

Main Methods:

  • Review of current literature on mTOR signaling in cancer.
  • Analysis of mTOR's involvement in angiogenesis and tumor immunity.
  • Examination of clinical trial data for mTOR inhibitors and combination therapies.

Main Results:

  • mTOR signaling influences TME composition and function.
  • mTOR modulates tumor angiogenesis and immune evasion.
  • Combinations of mTOR inhibitors and immune checkpoint inhibitors show clinical success.

Conclusions:

  • Targeting mTOR is a promising strategy to enhance anti-cancer immunity.
  • mTOR modulation offers potential for developing novel long-term cancer treatment strategies.
  • Further clinical trials are warranted to explore mTOR targeting in various cancers.
Keywords:
AngiogenesisCancerCombination therapyImmunotherapyTMETargeted therapyTumor–stroma interactionsmTOR pathwaymTORC1mTORC2

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