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Published on: August 12, 2019
Copper-Catalyzed Oxidative Thioamination of Maleimides with Amines and Bunte Salts
Shanshan Shi1, Yunfei Ma1, Jun Zhou1
1School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, People's Republic of China.
Abstract:
Herein, we describe the first example of copper-catalyzed oxidative thioamination of maleimides with secondary amines and Bunte salts with the achievement of C-N and C-S bonds in a single flask. The protocol showcases a prominently broad substrate scope and is also efficient for the late-stage modification of an array of pharmaceuticals. Preliminary mechanistic investigation indicates copper-catalyzed oxidative amination of maleimides with amines to form reactive enaminone and subsequent intermolecular alkenyl C-H thiolation.
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