Microgels and hydrogels as delivery systems for antimicrobial peptides

Area of Science:

• Biochemistry
• Materials Science
• Pharmacology

Background:

• Antibiotic resistance is a growing global health crisis, necessitating novel therapeutic strategies.
• Antimicrobial peptides (AMPs) are a promising alternative to conventional antibiotics.
• Challenges in AMP delivery, including peptide instability and charge, hinder their therapeutic application.

Purpose of the Study:

• To review microgels, polyelectrolyte complexes, and hydrogels as delivery systems for AMPs.
• To discuss critical factors influencing peptide loading and release from these delivery systems.
• To evaluate the impact of delivery systems on AMPs' antimicrobial efficacy and cytotoxicity.

Main Methods:

• Literature review focusing on AMP delivery systems.
• Analysis of factors affecting peptide encapsulation and release kinetics.
• Assessment of the functional performance of AMP-loaded delivery systems.

Main Results:

• Microgels, polyelectrolyte complexes, and hydrogels show potential for AMP delivery.
• Peptide loading and release are influenced by material properties and peptide characteristics.
• Delivery systems can modulate AMP activity and reduce toxicity.

Conclusions:

• Efficient AMP delivery systems are crucial for developing effective antimicrobial therapeutics.
• Careful design of hydrogels and microgels can overcome AMP delivery challenges.
• Further research into AMP-loaded delivery systems is warranted to combat antibiotic resistance.