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Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
Published on: February 9, 2024
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Detection of thyroiditis on PET/CT imaging: a systematic review
Domenico Albano1, Giorgio Treglia2,3,4, Luca Giovanella2,5
1Nuclear Medicine, University of Brescia and ASST Spedali Civili Brescia, Brescia, Italy. doalba87@libero.it.
Hormones (Athens, Greece)
|February 11, 2020
Summary
Diffuse thyroid uptake on PET scans is uncommon, often indicating benign thyroiditis. Malignancies with this pattern are rare, but further research is needed for accurate diagnosis and potential prognostic use.
Area of Science:
- Nuclear Medicine
- Radiology
- Endocrinology
Background:
- Thyroiditis detection via molecular imaging is understudied.
- Understanding the incidence and clinical significance of thyroiditis on PET/CT is crucial.
Purpose of the Study:
- To systematically review literature on thyroiditis detection using PET or PET/CT with various tracers.
- To analyze the metabolic appearance and clinical significance of thyroiditis identified by PET/CT.
Main Methods:
- Comprehensive literature search of Scopus, PubMed/MEDLINE, Embase, and Cochrane Library up to November 2019.
- Analysis of 26 selected articles focusing on PET/CT detection of thyroiditis.
Main Results:
- Diffuse thyroid uptake of PET tracers occurs in 0.4-46.2% of cases, usually benign.
- Thyroiditis is the most common cause of diffuse increased thyroid Fluorodeoxyglucose (FDG) uptake.
- Malignant disease with diffuse 18F-FDG uptake is infrequent; preliminary data suggests a role in treatment response and prognosis for immunotherapy patients.
Conclusions:
- Diffuse 18F-FDG thyroid uptake is rare and typically benign, with thyroiditis being the most frequent cause.
- Neoplastic disease presenting with diffuse 18F-FDG uptake is very uncommon.
- Further investigation of diffuse 18F-FDG thyroid uptake is warranted for accurate diagnosis and clinical evaluation.
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