[Secondary Neuroprotection in Glaucoma Through the Concepts of Complementary Drug Therapy]

Primary open angle glaucoma (POAG) is currently considered a neurodegenerative systemic disease. The individualised reduction in intraocular pressure alone does not do justice to the complex events in the chronic course of the disease, so that accompanying drug therapy concepts are useful. Based on four therapeutic strategies, such as the improvement of the mitochondrial respiratory chain with coenzyme Q10, the stabilisation of the mitochondrial and cellular plasma membranes with citicoline, the reduction in oxidative stress in the eye and in the body with curcumin and the improvement of fat metabolism, especially LDL cholesterol, with the application of statins, an insight into possible additive therapeutic approaches will be provided. Since neuroprotective therapies as monotherapies are unlikely to be very promising, they are more likely to consist of a combination of different therapeutic approaches.