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Hypothalamic lipoma and growth hormone deficiency

Anne Rochtus1,2, Joseph Vinckx2, Francis de Zegher2

  • 11Pediatric Neurology, University Hospitals Leuven, 3000 Leuven, Belgium.

International Journal of Pediatric Endocrinology
|February 12, 2020
PubMed

Insights

A rare hypothalamic lipoma was linked to growth hormone deficiency in a child. Growth hormone therapy successfully treated the short stature, suggesting a novel neuroendocrine connection.

Area of Science:

  • Neuroendocrinology
  • Pediatric Endocrinology

Background:

  • Intracranial lipomas are rare congenital midline lesions.
  • Hypothalamic lipomas are typically asymptomatic but can be associated with endocrine and neurological issues.

Observation:

  • A 7-year-old boy presented with short stature and partial growth hormone deficiency.
  • MRI revealed a paramedian hypothalamic lipoma.

Findings:

  • Growth hormone (GH) deficiency was identified in a patient with a hypothalamic lipoma.
  • GH treatment led to effective catch-up growth.

Implications:

  • This case may be the first to associate hypothalamic lipoma with GH deficiency.
  • Further research is needed to understand the neuroendocrine pathophysiology of this link.
Abstract

Keywords:
ChildGrowth hormone deficiencyHypothalamic lipomaIntracranial lipoma

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