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Carbon nanoparticles derived from carbon soot as a matrix for SALDI-MS analysis
Xueyun Wang1, Shuzhen Dou1, Zhongshun Wang1
1State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, People's Republic of China.
Mikrochimica Acta
|February 13, 2020
Summary
Candle soot-derived carbon nanoparticles (NPs) offer superior matrix performance for surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS). These washed carbon soot NPs (WCS NPs) provide high sensitivity, reproducibility, and stability for various analyses.
Area of Science:
- Analytical Chemistry
- Materials Science
Background:
- Developing efficient and stable matrices is crucial for surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS).
- Common matrices often suffer from high background noise or limited applicability across different ionization modes.
Purpose of the Study:
- To investigate the potential of carbon nanoparticles derived from candle soot as a novel matrix for SALDI-MS.
- To evaluate the performance, sensitivity, reproducibility, and stability of these carbon nanoparticles (NPs) as a SALDI-MS matrix.
Main Methods:
- Synthesized and purified carbon nanoparticles (NPs) from candle soot (WCS NPs, ~48 nm).
- Utilized WCS NPs as a matrix in SALDI-MS for analyzing diverse molecules in positive and negative ionization modes.
- Assessed detection limits, reproducibility, stability, and applied the matrix for urine glucose quantification, latent fingerprint visualization, and imaging.
Main Results:
- WCS NPs demonstrated higher laser desorption/ionization efficiency and lower background noise compared to conventional matrices.
- Achieved a low detection limit of 1 pmol for glucose.
- Showcased excellent reproducibility and high sensitivity for a broad range of analytes.
- Confirmed good stability of WCS NPs as a matrix after 10 months of storage.
Conclusions:
- Washed carbon soot nanoparticles (WCS NPs) are a highly effective, stable, and reproducible matrix for SALDI-MS.
- WCS NPs offer a promising alternative matrix for sensitive molecular analysis, including quantitative measurements and imaging applications.
