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Updated: Dec 28, 2025

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
Published on: December 10, 2010
Tripeptide-induced modulation of mesenchymal stem cell biomechanics stimulates proliferation and wound healing
Swati Sharma1, Chirag Kulkarni2, Manish M Kulkarni3
1Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India. sverma@iitk.ac.in.
Abstract:
We demonstrate the ability of two tripeptides to promote proliferation and modulate the mechanical properties of human mesenchymal stem cells (hMSCs). Notably, Young's modulus of peptide-treated hMSCs was found to be ∼2 fold higher compared to the control group. These peptides promoted wound healing in hMSCs, without stimulating osteogenic and adipogenic differentiation, thus showing high potential in vascular tissue engineering applications.

